4IG9

Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	NAD-dependent protein deacetylase sirtuin-1	polymer	281	31833.1	4	UniProt (Q96EB6) Pfam (PF02146)	Homo sapiens (human)	hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SirtT1 75 kDa fragment, 75SirT1
2	B, D, F, H (B, D, F, H)	NAD-dependent protein deacetylase sirtuin-1	polymer	31	3544.8	4	UniProt (Q96EB6)	Homo sapiens (human)
3	I, J, K, L (A, C, E, G)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, C, E, G: 234 - 510 (UniProt: Q96EB6)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag

B, D, F, H: 641 - 665 (UniProt: Q96EB6)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
His -4	-	expression tag
Met -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	141511.8
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	141773.4

*Water molecules are not included.