4IG9

Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070403	molecular_function	NAD+ binding
C	0070403	molecular_function	NAD+ binding
E	0070403	molecular_function	NAD+ binding
G	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS371
A	CYS374
A	CYS395
A	CYS398

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	CYS371
C	CYS374
C	CYS395
C	CYS398

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 601

Chain	Residue
E	CYS374
E	CYS395
E	CYS398
E	CYS371

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 601

Chain	Residue
G	CYS371
G	CYS374
G	CYS395
G	CYS398

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1040
Details	Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Required for interaction with the sumoylated form of CCAR2","evidences":[{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11672523","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12006491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17290224","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18235501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18485871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19934257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28497810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38512451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IXJ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CaMK2","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---