4IG9

Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070403	molecular_function	NAD+ binding
C	0070403	molecular_function	NAD+ binding
E	0070403	molecular_function	NAD+ binding
G	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS371
A	CYS374
A	CYS395
A	CYS398

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	CYS371
C	CYS374
C	CYS395
C	CYS398

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 601

Chain	Residue
E	CYS374
E	CYS395
E	CYS398
E	CYS371

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 601

Chain	Residue
G	CYS371
G	CYS374
G	CYS395
G	CYS398

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CaMK2 => ECO:0000250|UniProtKB:Q923E4

Chain	Residue	Details
B	SER659
D	SER659
F	SER659
H	SER659

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CaMK2 => ECO:0000305|PubMed:19236849

Chain	Residue	Details
B	SER661
E	GLN345
E	GLY440
E	ASN465
G	GLY261
G	GLN345
G	GLY440
G	ASN465
D	SER661
F	SER661
H	SER661
C	GLY261
C	GLN345
C	GLY440
C	ASN465
E	GLY261

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236

Chain	Residue	Details
A	CYS371
E	CYS374
E	CYS395
E	CYS398
G	CYS371
G	CYS374
G	CYS395
G	CYS398
A	CYS374
A	CYS395
A	CYS398
C	CYS371
C	CYS374
C	CYS395
C	CYS398
E	CYS371

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS482
C	CYS482
E	CYS482
G	CYS482

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q923E4

Chain	Residue	Details
A	LYS238
G	LYS238
G	LYS377
G	LYS430
A	LYS377
A	LYS430
C	LYS238
C	LYS377
C	LYS430
E	LYS238
E	LYS377
E	LYS430

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q923E4

Chain	Residue	Details
A	CYS395
A	CYS398
C	CYS395
C	CYS398
E	CYS395
E	CYS398
G	CYS395
G	CYS398

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