4IFP
X-ray Crystal Structure of Human NLRP1 CARD Domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Maltose-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 1 | polymer | 466 | 51696.6 | 3 | UniProt (P0AEX9) UniProt (Q9C000) Pfam (PF01547) Pfam (PF00619) In PDB | Escherichia coli | MBP,MMBP,Maltodextrin-binding protein,Caspase recruitment domain-containing protein 7,Death effector filament-forming ced-4-like apoptosis protein,Nucleotide-binding domain and caspase recruitment domain |
2 | D, E, F | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 3 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
3 | A, B, C | MALONATE ION | non-polymer | 102.0 | 3 | Chemie (MLI) | |||
4 | water | water | 18.0 | 1538 | Chemie (HOH) |
Sequence modifications
A, B, C: 2 - 367 (UniProt: P0AEX9)
A, B, C: 372 - 455 (UniProt: Q9C000)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ala 83 | Asp 108 | conflict |
Ala 84 | Lys 109 | conflict |
Ala 173 | Glu 198 | conflict |
Ala 174 | Asn 199 | conflict |
Ala 240 | Lys 265 | conflict |
Ala 360 | Glu 385 | conflict |
Ala 363 | Lys 388 | conflict |
Ala 364 | Asp 389 | conflict |
Asn 368 | - | linker |
Ala 369 | - | linker |
Val 370 | - | linker |
Asp 371 | - | linker |
PDB | External Database | Details |
---|---|---|
Ala 456 | - | expression tag |
Ala 457 | - | expression tag |
Ala 458 | - | expression tag |
Leu 459 | - | expression tag |
Glu 460 | - | expression tag |
His 461 | - | expression tag |
His 462 | - | expression tag |
His 463 | - | expression tag |
His 464 | - | expression tag |
His 465 | - | expression tag |
His 466 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 155089.7 | |
Branched | Number of molecules | 3 |
Total formula weight | 1026.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 306.1 | |
All* | Total formula weight | 156422.7 |