4IF6

Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 2.25 A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NAD-dependent protein deacetylase sirtuin-1	polymer	281	31833.1	1	UniProt (Q96EB6) Pfam (PF02146) In PDB	Homo sapiens (human)	hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SirtT1 75 kDa fragment, 75SirT1
2	B	NAD-dependent protein deacetylase sirtuin-1	polymer	31	3544.8	1	UniProt (Q96EB6) In PDB	Homo sapiens (human)
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	ADENOSINE-5-DIPHOSPHORIBOSE	non-polymer		559.3	1	Chemie (APR)
5		water	water		18.0	209	Chemie (HOH)

Sequence modifications

A: 234 - 510 (UniProt: Q96EB6)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag

B: 641 - 665 (UniProt: Q96EB6)

PDB	External Database	Details
Gly -6	-	expression tag
Pro -5	-	expression tag
His -4	-	expression tag
Met -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35377.9
Non-Polymers*	Number of molecules	2
	Total formula weight	624.7
All*	Total formula weight	36002.7

*Water molecules are not included.