4IF6
Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 2.25 A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-1 | polymer | 281 | 31833.1 | 1 | UniProt (Q96EB6) Pfam (PF02146) | Homo sapiens (human) | hSIRT1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1, hSIR2, SirtT1 75 kDa fragment, 75SirT1 |
| 2 | B (B) | NAD-dependent protein deacetylase sirtuin-1 | polymer | 31 | 3544.8 | 1 | UniProt (Q96EB6) | Homo sapiens (human) | |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 559.3 | 1 | Chemie (APR) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 234 - 510 (UniProt: Q96EB6)
B: 641 - 665 (UniProt: Q96EB6)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| His -2 | - | expression tag |
| Met -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Pro -5 | - | expression tag |
| His -4 | - | expression tag |
| Met -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35377.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 624.7 | |
| All* | Total formula weight | 36002.7 |
