4IF6

Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 2.25 A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS371
A	CYS374
A	CYS395
A	CYS398

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site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE APR A 602

Chain	Residue
A	PHE273
A	ARG274
A	TYR280
A	GLN345
A	HIS363
A	GLY440
A	SER441
A	SER442
A	VAL445
A	ASN465
A	ARG466
A	GLU467
A	GLY480
A	ASP481
A	CYS482
A	HOH711
A	HOH791
A	HOH809
A	HOH862
A	GLY261
A	ALA262
A	GLY263
A	VAL266
A	ASP272

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CaMK2 => ECO:0000250|UniProtKB:Q923E4

Chain	Residue	Details
B	SER659

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CaMK2 => ECO:0000305|PubMed:19236849

Chain	Residue	Details
A	GLN345
A	GLY440
A	ASN465
B	SER661

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236

Chain	Residue	Details
A	CYS371
A	CYS374
A	CYS395
A	CYS398

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS482

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site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q923E4

Chain	Residue	Details
A	LYS238
A	LYS377
A	LYS430

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q923E4

Chain	Residue	Details
A	CYS395
A	CYS398

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