4ID5
HIV-1 reverse transcriptase with bound fragment at the RNase H primer grip site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 557 | 63989.2 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 (HIV-1) | EXORIBONUCLEASE H, P66 RT |
| 2 | B (B) | P51 RT | polymer | 429 | 50096.5 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 (HIV-1) | Gag-Pol polyprotein |
| 3 | C (A) | 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile | non-polymer | 366.4 | 1 | Chemie (T27) | |||
| 4 | D, E, F, G, H... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 17 | Chemie (DMS) | |||
| 5 | K (A) | 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid | non-polymer | 202.2 | 1 | Chemie (1FF) | |||
| 6 | L (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | W, X (A, B) | water | water | 18.0 | 889 | Chemie (HOH) |
Sequence modifications
A: 1 - 555 (UniProt: P03366)
B: 1 - 428 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Val 0 | - | expression tag |
| Ala 172 | Lys 771 | engineered mutation |
| Ala 173 | Lys 772 | engineered mutation |
| Ser 280 | Cys 879 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114085.8 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1921.2 | |
| All* | Total formula weight | 116007.0 |
