4IAQ
Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562 | polymer | 403 | 45517.0 | 1 | UniProt (P28222) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens | 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta receptor, 5-HT-1D-beta, Serotonin receptor 1B |
| 2 | B (A) | Dihydroergotamine | non-polymer | 583.7 | 1 | Chemie (2GM) | |||
| 3 | C (A) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 33 - 239 (UniProt: P28222)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 304 - 390 (UniProt: P28222)
| PDB | External Database | Details |
|---|---|---|
| Gly 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Thr 32 | - | expression tag |
| Trp 138 | Leu 138 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45517.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 583.7 | |
| All* | Total formula weight | 46100.7 |
