4IAQ

Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004993	molecular_function	G protein-coupled serotonin receptor activity
A	0005506	molecular_function	iron ion binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 2GM A 2001

Chain	Residue
A	ASP129
A	PHE330
A	LEU348
A	PHE351
A	ASP352
A	THR355
A	ILE130
A	CYS133
A	THR134
A	CYS199
A	VAL200
A	VAL201
A	ALA216
A	TRP327

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Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCVIALDRYWaI

Chain	Residue	Details
A	ALA135-ILE151

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	PRO47-ALA72

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site_id	SWS_FT_FI2
Number of Residues	51
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	THR73-TYR86
A	ASP146-ARG165
A	MET371-SER390

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	LEU87-VAL111

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	THR112-GLN119
A	PHE185-HIS205
A	PRO338-HIS347

---

site_id	SWS_FT_FI5
Number of Residues	25
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	VAL120-LEU145

---

site_id	SWS_FT_FI6
Number of Residues	18
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	ALA166-PRO184

---

site_id	SWS_FT_FI7
Number of Residues	23
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	ILE206-GLY229

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	LEU316-MET337

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:29925951, ECO:0007744|PDB:6G79

Chain	Residue	Details
A	LEU348-THR370

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:23519210, ECO:0007744|PDB:4IAR

Chain	Residue	Details
A	ASP129
A	THR134
A	VAL201

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	SITE: Important for species-specific agonist sensitivity => ECO:0000269|PubMed:23519210

Chain	Residue	Details
A	THR355

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site_id	SWS_FT_FI12
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
A	CYS388

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site_id	SWS_FT_FI13
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

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