4I9O

Crystal Structure of GACKIX L664C Tethered to 1-10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CREB-binding protein	polymer	101	12139.2	1	UniProt (P45481) Pfam (PF02172)	Mus musculus (mouse)
2	B (A)	1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one	non-polymer		367.8	1	Chemie (KI1)
3	C, D (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	E (A)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

A: 586 - 672 (UniProt: P45481)

PDB	External Database	Details
Mse 572	-	expression tag
Arg 573	-	expression tag
Gly 574	-	expression tag
Ser 575	-	expression tag
His 576	-	expression tag
His 577	-	expression tag
His 578	-	expression tag
His 579	-	expression tag
His 580	-	expression tag
His 581	-	expression tag
Gly 582	-	expression tag
Mse 583	-	expression tag
Ala 584	-	expression tag
Ser 585	-	expression tag
Cys 664	Leu 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	12139.2
Non-Polymers*	Number of molecules	3
	Total formula weight	492.0
All*	Total formula weight	12631.2

*Water molecules are not included.