4I74
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 and allosterically inhibited by a Ni2+ ion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Inosine-adenosine-guanosine-nucleoside hydrolase | polymer | 330 | 36167.6 | 1 | UniProt (Q57ZL6) Pfam (PF01156) In PDB | Trypanosoma brucei brucei | |
| 2 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 3 | A | NICKEL (II) ION | non-polymer | 58.7 | 7 | Chemie (NI) | |||
| 4 | A | (2R,3R,4S)-2-(hydroxymethyl)-1-[(4-hydroxythieno[3,2-d]pyrimidin-7-yl)methyl]pyrrolidine-3,4-diol | non-polymer | 297.3 | 1 | Chemie (MBY) | |||
| 5 | A | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 1 - 327 (UniProt: Q57ZL6)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | EXPRESSION TAG |
| Ser -1 | - | EXPRESSION TAG |
| His 0 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36167.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 870.4 | |
| All* | Total formula weight | 37038.0 |
