4I74
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 and allosterically inhibited by a Ni2+ ion
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0008477 | molecular_function | purine nucleosidase activity |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
A | 0020015 | cellular_component | glycosome |
A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CA A 401 |
Chain | Residue |
A | ASP10 |
A | ASP15 |
A | THR137 |
A | ASP261 |
A | NI406 |
A | MBY408 |
A | TRS409 |
A | HOH527 |
A | HOH742 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NI A 402 |
Chain | Residue |
A | HIS58 |
A | HOH661 |
A | HOH696 |
A | HOH704 |
A | HOH751 |
A | HOH764 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NI A 403 |
Chain | Residue |
A | HIS115 |
A | HOH639 |
A | HOH735 |
A | HOH737 |
A | HOH765 |
A | HOH766 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NI A 404 |
Chain | Residue |
A | HIS317 |
A | HOH541 |
A | HOH703 |
A | HOH725 |
A | HOH772 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NI A 405 |
Chain | Residue |
A | GLY-2 |
A | SER-1 |
A | HIS0 |
A | MET1 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NI A 406 |
Chain | Residue |
A | ASP14 |
A | ASP40 |
A | CA401 |
A | TRS409 |
A | HOH742 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NI A 407 |
Chain | Residue |
A | ASP190 |
A | HOH540 |
A | HOH728 |
A | HOH729 |
A | HOH755 |
A | HOH780 |
site_id | AC8 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE MBY A 408 |
Chain | Residue |
A | ASN12 |
A | ASP14 |
A | ASP15 |
A | ASP40 |
A | PHE79 |
A | TRP83 |
A | THR137 |
A | MET164 |
A | ASN173 |
A | GLU184 |
A | TRP185 |
A | ASN186 |
A | GLU248 |
A | GLU249 |
A | TRP260 |
A | ASP261 |
A | CA401 |
A | HOH527 |
A | HOH607 |
A | HOH742 |
site_id | AC9 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE TRS A 409 |
Chain | Residue |
A | ASP14 |
A | ASP40 |
A | PHE79 |
A | THR137 |
A | MET164 |
A | ASN173 |
A | GLU184 |
A | TRP185 |
A | ASN186 |
A | TRP260 |
A | ASP261 |
A | CA401 |
A | NI406 |
A | HOH527 |
A | HOH742 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NI A 410 |
Chain | Residue |
A | GLU82 |
A | GLU82 |
A | HIS247 |
A | HIS247 |
A | HOH720 |
A | HOH757 |
A | HOH757 |