4I74

Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312 and allosterically inhibited by a Ni2+ ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0008477	molecular_function	purine nucleosidase activity
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0020015	cellular_component	glycosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CA A 401

Chain	Residue
A	ASP10
A	ASP15
A	THR137
A	ASP261
A	NI406
A	MBY408
A	TRS409
A	HOH527
A	HOH742

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 402

Chain	Residue
A	HIS58
A	HOH661
A	HOH696
A	HOH704
A	HOH751
A	HOH764

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 403

Chain	Residue
A	HIS115
A	HOH639
A	HOH735
A	HOH737
A	HOH765
A	HOH766

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 404

Chain	Residue
A	HIS317
A	HOH541
A	HOH703
A	HOH725
A	HOH772

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI A 405

Chain	Residue
A	GLY-2
A	SER-1
A	HIS0
A	MET1

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 406

Chain	Residue
A	ASP14
A	ASP40
A	CA401
A	TRS409
A	HOH742

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 407

Chain	Residue
A	ASP190
A	HOH540
A	HOH728
A	HOH729
A	HOH755
A	HOH780

---

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE MBY A 408

Chain	Residue
A	ASN12
A	ASP14
A	ASP15
A	ASP40
A	PHE79
A	TRP83
A	THR137
A	MET164
A	ASN173
A	GLU184
A	TRP185
A	ASN186
A	GLU248
A	GLU249
A	TRP260
A	ASP261
A	CA401
A	HOH527
A	HOH607
A	HOH742

---

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TRS A 409

Chain	Residue
A	ASP14
A	ASP40
A	PHE79
A	THR137
A	MET164
A	ASN173
A	GLU184
A	TRP185
A	ASN186
A	TRP260
A	ASP261
A	CA401
A	NI406
A	HOH527
A	HOH742

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NI A 410

Chain	Residue
A	GLU82
A	GLU82
A	HIS247
A	HIS247
A	HOH720
A	HOH757
A	HOH757

---