4I4F
Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric binding pyrazolobenzothiazine compound.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Focal adhesion kinase 1 | polymer | 281 | 32120.1 | 1 | UniProt (Q05397) Pfam (PF07714) | Homo sapiens (human) | FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK |
| 2 | B (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 3 | C (A) | N-(4-tert-butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxide | non-polymer | 410.5 | 1 | Chemie (1BR) | |||
| 4 | D (A) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 411 - 686 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 406 | - | expression tag |
| Ala 407 | - | expression tag |
| Met 408 | - | expression tag |
| Gly 409 | - | expression tag |
| Ser 410 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32120.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 470.6 | |
| All* | Total formula weight | 32590.8 |
