4HVC
Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional glutamate/proline--tRNA ligase | polymer | 519 | 59063.5 | 2 | UniProt (P07814) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Homo sapiens (human) | Bifunctional aminoacyl-tRNA synthetase, Cell proliferation-inducing gene 32 protein, Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS, Proline--tRNA ligase, Prolyl-tRNA synthetase |
| 2 | C, G (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 3 | D, H (A, B) | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 4 | E, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A, B: 1003 - 1512 (UniProt: P07814)
| PDB | External Database | Details |
|---|---|---|
| Met 994 | - | expression tag |
| His 995 | - | expression tag |
| His 996 | - | expression tag |
| His 997 | - | expression tag |
| His 998 | - | expression tag |
| His 999 | - | expression tag |
| His 1000 | - | expression tag |
| Gly 1001 | - | expression tag |
| Ser 1002 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 118126.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2021.2 | |
| All* | Total formula weight | 120148.1 |
