4HVC
Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ANP A 1601 |
| Chain | Residue |
| A | ARG1152 |
| A | THR1276 |
| A | ARG1278 |
| A | HFG1602 |
| A | MG1603 |
| A | HOH1736 |
| A | HOH1780 |
| A | HOH1793 |
| A | GLU1154 |
| A | PHE1161 |
| A | ARG1163 |
| A | THR1164 |
| A | PHE1167 |
| A | GLN1237 |
| A | GLY1239 |
| A | THR1240 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HFG A 1602 |
| Chain | Residue |
| A | HIS1093 |
| A | PHE1097 |
| A | GLU1100 |
| A | VAL1101 |
| A | PRO1120 |
| A | THR1121 |
| A | GLU1123 |
| A | ARG1152 |
| A | TRP1169 |
| A | GLU1171 |
| A | HIS1173 |
| A | PHE1216 |
| A | HIS1242 |
| A | TRP1273 |
| A | GLY1274 |
| A | ANP1601 |
| A | HOH1794 |
| A | HOH1805 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1603 |
| Chain | Residue |
| A | ANP1601 |
| A | HOH1793 |
| A | HOH1794 |
| A | HOH1795 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1604 |
| Chain | Residue |
| A | CYS1448 |
| A | CYS1453 |
| A | CYS1495 |
| A | CYS1497 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ANP B 1601 |
| Chain | Residue |
| B | ARG1152 |
| B | GLU1154 |
| B | PHE1161 |
| B | LEU1162 |
| B | ARG1163 |
| B | THR1164 |
| B | PHE1167 |
| B | TRP1169 |
| B | GLN1237 |
| B | THR1240 |
| B | THR1276 |
| B | ARG1278 |
| B | HFG1602 |
| B | MG1603 |
| B | HOH1702 |
| B | HOH1706 |
| B | HOH1719 |
| B | HOH1725 |
| B | HOH1743 |
| B | HOH1752 |
| B | HOH1778 |
| B | HOH1784 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HFG B 1602 |
| Chain | Residue |
| B | HIS1093 |
| B | PHE1097 |
| B | GLU1100 |
| B | VAL1101 |
| B | PRO1120 |
| B | THR1121 |
| B | GLU1123 |
| B | ARG1152 |
| B | TRP1169 |
| B | PHE1216 |
| B | HIS1242 |
| B | TRP1273 |
| B | GLY1274 |
| B | ANP1601 |
| B | HOH1706 |
| B | HOH1766 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1603 |
| Chain | Residue |
| B | ANP1601 |
| B | HOH1706 |
| B | HOH1719 |
| B | HOH1778 |
| B | HOH1784 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1604 |
| Chain | Residue |
| B | CYS1448 |
| B | CYS1453 |
| B | CYS1495 |
| B | CYS1497 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24100331, ECO:0007744|PDB:4K87 |
| Chain | Residue | Details |
| A | THR1121 | |
| A | ARG1152 | |
| A | HIS1242 | |
| B | THR1121 | |
| B | ARG1152 | |
| B | HIS1242 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K87, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | GLU1154 | |
| B | THR1276 | |
| A | ARG1163 | |
| A | THR1164 | |
| A | THR1240 | |
| A | THR1276 | |
| B | GLU1154 | |
| B | ARG1163 | |
| B | THR1164 | |
| B | THR1240 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37212275, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | GLN1237 | |
| A | ARG1278 | |
| B | GLN1237 | |
| B | ARG1278 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:5V58, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | CYS1448 | |
| B | CYS1448 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | CYS1453 | |
| A | CYS1497 | |
| B | CYS1453 | |
| B | CYS1497 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23263184, ECO:0000269|PubMed:24100331, ECO:0000269|PubMed:29273753, ECO:0000269|PubMed:37212275, ECO:0007744|PDB:4HVC, ECO:0007744|PDB:4K86, ECO:0007744|PDB:4K87, ECO:0007744|PDB:4K88, ECO:0007744|PDB:5V58, ECO:0007744|PDB:7Y1H, ECO:0007744|PDB:7Y1W, ECO:0007744|PDB:7Y28, ECO:0007744|PDB:7Y3S |
| Chain | Residue | Details |
| A | CYS1495 | |
| B | CYS1495 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | ARG1152 | |
| B | ARG1152 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1350 | |
| B | SER1350 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS1503 | |
| B | LYS1503 |
