4HVC

Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004827	molecular_function	proline-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006433	biological_process	prolyl-tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004827	molecular_function	proline-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006433	biological_process	prolyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP A 1601

Chain	Residue
A	ARG1152
A	THR1276
A	ARG1278
A	HFG1602
A	MG1603
A	HOH1736
A	HOH1780
A	HOH1793
A	GLU1154
A	PHE1161
A	ARG1163
A	THR1164
A	PHE1167
A	GLN1237
A	GLY1239
A	THR1240

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HFG A 1602

Chain	Residue
A	HIS1093
A	PHE1097
A	GLU1100
A	VAL1101
A	PRO1120
A	THR1121
A	GLU1123
A	ARG1152
A	TRP1169
A	GLU1171
A	HIS1173
A	PHE1216
A	HIS1242
A	TRP1273
A	GLY1274
A	ANP1601
A	HOH1794
A	HOH1805

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1603

Chain	Residue
A	ANP1601
A	HOH1793
A	HOH1794
A	HOH1795

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1604

Chain	Residue
A	CYS1448
A	CYS1453
A	CYS1495
A	CYS1497

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ANP B 1601

Chain	Residue
B	ARG1152
B	GLU1154
B	PHE1161
B	LEU1162
B	ARG1163
B	THR1164
B	PHE1167
B	TRP1169
B	GLN1237
B	THR1240
B	THR1276
B	ARG1278
B	HFG1602
B	MG1603
B	HOH1702
B	HOH1706
B	HOH1719
B	HOH1725
B	HOH1743
B	HOH1752
B	HOH1778
B	HOH1784

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HFG B 1602

Chain	Residue
B	HIS1093
B	PHE1097
B	GLU1100
B	VAL1101
B	PRO1120
B	THR1121
B	GLU1123
B	ARG1152
B	TRP1169
B	PHE1216
B	HIS1242
B	TRP1273
B	GLY1274
B	ANP1601
B	HOH1706
B	HOH1766

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 1603

Chain	Residue
B	ANP1601
B	HOH1706
B	HOH1719
B	HOH1778
B	HOH1784

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1604

Chain	Residue
B	CYS1448
B	CYS1453
B	CYS1495
B	CYS1497

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29273753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29273753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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