4HT2
Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Carbonic anhydrase 12 | polymer | 263 | 29917.3 | 4 | UniProt (O43570) Pfam (PF00194) In PDB | Homo sapiens (human) | Carbonate dehydratase XII, Carbonic anhydrase XII, CA-XII, Tumor antigen HOM-RCC-3.1.3 |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide | non-polymer | 367.3 | 4 | Chemie (V50) | |||
4 | A, B, D | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
5 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
6 | water | water | 18.0 | 1504 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 263 (UniProt: O43570)
PDB | External Database | Details |
---|---|---|
Met 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 119669.3 | |
Non-Polymers* | Number of molecules | 23 |
Total formula weight | 2794.2 | |
All* | Total formula weight | 122463.5 |