4HSA
Structure of interleukin 17a in complex with il17ra receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, E (A, B, D, E) | Interleukin-17A | polymer | 122 | 14120.8 | 4 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8 |
| 2 | C, F (C, F) | Interleukin-17 receptor A | polymer | 301 | 34856.3 | 2 | UniProt (Q96F46) Pfam (PF16556) Pfam (PF16578) | Homo sapiens (human) | IL-17 receptor A, IL-17RA, CDw217 |
| 3 | G, J (G, J) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 2 | In PDB GlyTouCan (G26032DN) | |||
| 4 | H (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | I (I) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | K (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | L, M, N (B, C, E) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 11 - 132 (UniProt: Q16552)
C, F: 1 - 286 (UniProt: Q96F46)
| PDB | External Database | Details |
|---|---|---|
| Asp 45 | Asn 68 | engineered mutation |
| Ser 106 | Cys 129 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 175 | Asn 206 | engineered mutation |
| Asp 234 | Asn 265 | engineered mutation |
| Leu 287 | - | expression tag |
| Val 288 | - | expression tag |
| Pro 289 | - | expression tag |
| Arg 290 | - | expression tag |
| Gly 291 | - | expression tag |
| Ser 292 | - | expression tag |
| Asp 293 | - | expression tag |
| Tyr 294 | - | expression tag |
| Lys 295 | - | expression tag |
| Asp 296 | - | expression tag |
| Asp 297 | - | expression tag |
| Asp 298 | - | expression tag |
| Asp 299 | - | expression tag |
| Lys 300 | - | expression tag |
| Gly 301 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 126196.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2727.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 129144.7 |
