4HSA

Structure of interleukin 17a in complex with il17ra receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002225	biological_process	positive regulation of antimicrobial peptide production
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007219	biological_process	Notch signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0008219	biological_process	cell death
A	0009611	biological_process	response to wounding
A	0009897	cellular_component	external side of plasma membrane
A	0010467	biological_process	gene expression
A	0030216	biological_process	keratinocyte differentiation
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032739	biological_process	positive regulation of interleukin-16 production
A	0032747	biological_process	positive regulation of interleukin-23 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0038173	biological_process	interleukin-17A-mediated signaling pathway
A	0042803	molecular_function	protein homodimerization activity
A	0043616	biological_process	keratinocyte proliferation
A	0045087	biological_process	innate immune response
A	0045672	biological_process	positive regulation of osteoclast differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046982	molecular_function	protein heterodimerization activity
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0050832	biological_process	defense response to fungus
A	0060729	biological_process	intestinal epithelial structure maintenance
A	0071347	biological_process	cellular response to interleukin-1
A	0072537	biological_process	fibroblast activation
A	0097400	biological_process	interleukin-17-mediated signaling pathway
A	0097530	biological_process	granulocyte migration
A	0106015	biological_process	negative regulation of inflammatory response to wounding
A	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
A	1903348	biological_process	positive regulation of bicellular tight junction assembly
A	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
B	0002225	biological_process	positive regulation of antimicrobial peptide production
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006915	biological_process	apoptotic process
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007219	biological_process	Notch signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0008219	biological_process	cell death
B	0009611	biological_process	response to wounding
B	0009897	cellular_component	external side of plasma membrane
B	0010467	biological_process	gene expression
B	0030216	biological_process	keratinocyte differentiation
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032735	biological_process	positive regulation of interleukin-12 production
B	0032739	biological_process	positive regulation of interleukin-16 production
B	0032747	biological_process	positive regulation of interleukin-23 production
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0038173	biological_process	interleukin-17A-mediated signaling pathway
B	0042803	molecular_function	protein homodimerization activity
B	0043616	biological_process	keratinocyte proliferation
B	0045087	biological_process	innate immune response
B	0045672	biological_process	positive regulation of osteoclast differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046982	molecular_function	protein heterodimerization activity
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0050832	biological_process	defense response to fungus
B	0060729	biological_process	intestinal epithelial structure maintenance
B	0071347	biological_process	cellular response to interleukin-1
B	0072537	biological_process	fibroblast activation
B	0097400	biological_process	interleukin-17-mediated signaling pathway
B	0097530	biological_process	granulocyte migration
B	0106015	biological_process	negative regulation of inflammatory response to wounding
B	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
B	1903348	biological_process	positive regulation of bicellular tight junction assembly
B	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
C	0030368	molecular_function	interleukin-17 receptor activity
D	0002225	biological_process	positive regulation of antimicrobial peptide production
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006915	biological_process	apoptotic process
D	0006954	biological_process	inflammatory response
D	0006955	biological_process	immune response
D	0007219	biological_process	Notch signaling pathway
D	0007267	biological_process	cell-cell signaling
D	0008219	biological_process	cell death
D	0009611	biological_process	response to wounding
D	0009897	cellular_component	external side of plasma membrane
D	0010467	biological_process	gene expression
D	0030216	biological_process	keratinocyte differentiation
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032735	biological_process	positive regulation of interleukin-12 production
D	0032739	biological_process	positive regulation of interleukin-16 production
D	0032747	biological_process	positive regulation of interleukin-23 production
D	0032755	biological_process	positive regulation of interleukin-6 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0038173	biological_process	interleukin-17A-mediated signaling pathway
D	0042803	molecular_function	protein homodimerization activity
D	0043616	biological_process	keratinocyte proliferation
D	0045087	biological_process	innate immune response
D	0045672	biological_process	positive regulation of osteoclast differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046982	molecular_function	protein heterodimerization activity
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0050832	biological_process	defense response to fungus
D	0060729	biological_process	intestinal epithelial structure maintenance
D	0071347	biological_process	cellular response to interleukin-1
D	0072537	biological_process	fibroblast activation
D	0097400	biological_process	interleukin-17-mediated signaling pathway
D	0097530	biological_process	granulocyte migration
D	0106015	biological_process	negative regulation of inflammatory response to wounding
D	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
D	1903348	biological_process	positive regulation of bicellular tight junction assembly
D	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
E	0002225	biological_process	positive regulation of antimicrobial peptide production
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006915	biological_process	apoptotic process
E	0006954	biological_process	inflammatory response
E	0006955	biological_process	immune response
E	0007219	biological_process	Notch signaling pathway
E	0007267	biological_process	cell-cell signaling
E	0008219	biological_process	cell death
E	0009611	biological_process	response to wounding
E	0009897	cellular_component	external side of plasma membrane
E	0010467	biological_process	gene expression
E	0030216	biological_process	keratinocyte differentiation
E	0032731	biological_process	positive regulation of interleukin-1 beta production
E	0032735	biological_process	positive regulation of interleukin-12 production
E	0032739	biological_process	positive regulation of interleukin-16 production
E	0032747	biological_process	positive regulation of interleukin-23 production
E	0032755	biological_process	positive regulation of interleukin-6 production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0038173	biological_process	interleukin-17A-mediated signaling pathway
E	0042803	molecular_function	protein homodimerization activity
E	0043616	biological_process	keratinocyte proliferation
E	0045087	biological_process	innate immune response
E	0045672	biological_process	positive regulation of osteoclast differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046982	molecular_function	protein heterodimerization activity
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0050832	biological_process	defense response to fungus
E	0060729	biological_process	intestinal epithelial structure maintenance
E	0071347	biological_process	cellular response to interleukin-1
E	0072537	biological_process	fibroblast activation
E	0097400	biological_process	interleukin-17-mediated signaling pathway
E	0097530	biological_process	granulocyte migration
E	0106015	biological_process	negative regulation of inflammatory response to wounding
E	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
E	1903348	biological_process	positive regulation of bicellular tight junction assembly
E	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
F	0030368	molecular_function	interleukin-17 receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:23695682

Chain	Residue	Details
C	ASN18
C	ASN23
C	ASN194
F	ASN18
F	ASN23
F	ASN194

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19838198

Chain	Residue	Details
C	ASN36
C	ASP234
F	ASN36
F	ASP234

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASP175
C	ASN211
F	ASP175
F	ASN211

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