4HPT
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase displaying complete phosphoryl transfer of AMP-PNP onto a substrate peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40657.3 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus (mouse) | PKA C-alpha |
| 2 | B (I) | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2279.4 | 1 | UniProt (P63248) | Mus musculus | PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform |
| 3 | C (E) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D, E (E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, G (E, I) | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
I: 5 - 24 (UniProt: P63248)
| PDB | External Database | Details |
|---|---|---|
| Ala 20 | Asn 21 | engineered mutation |
| Sep 21 | Ala 22 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42936.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 554.8 | |
| All* | Total formula weight | 43491.5 |
