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4HON

Crystal structure of human JMJD2D/KDM4D in complex with an H3K9me3 peptide and 2-oxoglutarate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Lysine-specific demethylase 4Dpolymer33038137.22UniProt (Q6B0I6)
Pfam (PF02375)
Pfam (PF02373)
Homo sapiens (human)JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D
2C, D
(F, G)
Histone H3 Peptidepolymer101021.22UniProt (by SIFTS) (P68431)Homo sapiens
3E, W
(A, B)
2-OXOGLUTARIC ACIDnon-polymer146.12Chemie (AKG)
4F, X
(A, B)
NICKEL (II) IONnon-polymer58.72Chemie (NI)
5G, Y
(A, B)
ZINC IONnon-polymer65.42Chemie (ZN)
6AA, BA, H, I, J...
(B, A)
THIOCYANATE IONnon-polymer58.16Chemie (SCN)
7CA, DA, EA, FA, K...
(B, A)
NITRATE IONnon-polymer62.012Chemie (NO3)
8GA, S, T, U, V
(B, A)
1,3-PROPANDIOLnon-polymer76.15Chemie (PDO)
9HA, IA, JA
(A, B, F)
waterwater18.0408Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight78316.7
Non-Polymers*Number of molecules29
Total formula weight2013.4
All*Total formula weight80330.1
*Water molecules are not included.

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PDB entries from 2025-12-03

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