4HN5

GR DNA Binding Domain - TSLP nGRE Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Glucocorticoid receptor	polymer	117	13032.1	2	UniProt (P04150) Pfam (PF00105)	Homo sapiens (human)	GR, Nuclear receptor subfamily 3 group C member 1
2	B (C)	DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3')	polymer	16	4900.2	1		synthetic construct
3	C (D)	DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3')	polymer	16	4900.2	1		synthetic construct
4	E, F, G, H (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	I, J, K, L (A, C, D, B)	water	water		18.0	162	Chemie (HOH)

Sequence modifications

A, B: 417 - 506 (UniProt: P04150)

PDB	External Database	Details
Met 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
Ser 397	-	expression tag
Ser 398	-	expression tag
Gly 399	-	expression tag
Val 400	-	expression tag
Asp 401	-	expression tag
Leu 402	-	expression tag
Gly 403	-	expression tag
Thr 404	-	expression tag
Glu 405	-	expression tag
Asn 406	-	expression tag
Leu 407	-	expression tag
Tyr 408	-	expression tag
Phe 409	-	expression tag
Gln 410	-	expression tag
Ser 411	-	expression tag
Asn 412	-	expression tag
Ala 413	-	expression tag
Ser 414	-	expression tag
Asn 415	-	expression tag
Ala 416	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	35864.5
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	36126.1

*Water molecules are not included.