4HJX

Crystal structure of F2YRS complexed with F2Y

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-tRNA ligase	polymer	314	36051.8	2	UniProt (Q57834) Pfam (PF00579)	Methanococcus Jannaschii DSM 2661	Tyrosyl-tRNA synthetase, TyrRS
2	C, D (A, B)	3,5-difluoro-L-tyrosine	non-polymer		217.2	2	Chemie (F2Y)
3	E, F (A, B)	water	water		18.0	64	Chemie (HOH)

Sequence modifications

A, B: 1 - 306 (UniProt: Q57834)

PDB	External Database	Details
Arg 32	Tyr 32	engineered mutation
Tyr 65	Leu 65	engineered mutation
Gly 70	His 70	engineered mutation
Asn 108	Phe 108	engineered mutation
Cys 109	Gln 109	engineered mutation
Asn 158	Asp 158	engineered mutation
Ser 162	Leu 162	engineered mutation
Leu 307	-	expression tag
Glu 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72103.6
Non-Polymers*	Number of molecules	2
	Total formula weight	434.3
All*	Total formula weight	72537.9

*Water molecules are not included.