4HJ0

Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Gastric inhibitory polypeptide receptor	polymer	136	15764.3	2	UniProt (P48546) Pfam (PF02793)	Homo sapiens (human)	GIP-R, Glucose-dependent insulinotropic polypeptide receptor
2	C, F (P, C)	Gipg013 Fab, Antagonizing antibody to the GIP Receptor, Heavy chain	polymer	227	23758.6	2		Homo sapiens (human)
3	D, E (Q, D)	Gipg013 Fab, Antagonizing antibody to the GIP Receptor, Light chain	polymer	215	22691.9	2		Homo sapiens (human)

Sequence modifications

A, B: 24 - 138 (UniProt: P48546)

PDB	External Database	Details
Met 3	-	expression tag
Gly 4	-	expression tag
Ser 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
Ser 13	-	expression tag
Asp 14	-	expression tag
Tyr 15	-	expression tag
Lys 16	-	expression tag
Asp 17	-	expression tag
Asp 18	-	expression tag
Asp 19	-	expression tag
Asp 20	-	expression tag
Lys 21	-	expression tag
His 22	-	expression tag
Met 23	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	124429.6
All*	Total formula weight	124429.6

*Water molecules are not included.