4HEU
Crystal Structure of PDE10A with a biaryl ether inhibitor ((1-(3-(4-((1H-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 318 | 36857.4 | 2 | UniProt (Q9Y233) | Homo sapiens (human) | |
| 2 | C, D, L, M (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, F, G, H, I... (A, B) | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
| 4 | K, T (A, B) | (1-{3-[4-(1H-benzimidazol-2-ylamino)phenoxy]pyridin-2-yl}piperidin-4-yl)methanol | non-polymer | 415.5 | 2 | Chemie (15J) | |||
| 5 | U, V (A, B) | water | water | 18.0 | 400 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73714.9 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2245.4 | |
| All* | Total formula weight | 75960.3 |
