Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS519 |
| A | HIS553 |
| A | ASP554 |
| A | ASP664 |
| A | ZN1002 |
| A | HOH1159 |
| A | HOH1275 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1002 |
| Chain | Residue |
| A | HOH1152 |
| A | HOH1153 |
| A | HOH1155 |
| A | HOH1156 |
| A | HOH1275 |
| A | ASP554 |
| A | ZN1001 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | PHE472 |
| A | GLU473 |
| A | ASN474 |
| A | ARG510 |
| A | ARG558 |
| A | HOH1276 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | LYS497 |
| A | LEU595 |
| A | GLY597 |
| A | HIS598 |
| A | ASN599 |
| A | HOH1111 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | VAL512 |
| A | PRO513 |
| A | ARG558 |
| A | GLY559 |
| A | GLU685 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | LEU537 |
| A | LEU646 |
| A | ASN647 |
| A | ARG652 |
| B | LEU646 |
| B | ARG652 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
| Chain | Residue |
| A | LEU625 |
| A | PHE719 |
| A | 15J1009 |
| A | HOH1233 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
| Chain | Residue |
| A | TRP672 |
| A | PRO673 |
| A | LYS676 |
| A | LYS694 |
| A | HOH1227 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 15J A 1009 |
| Chain | Residue |
| A | TYR514 |
| A | LEU665 |
| A | THR675 |
| A | ALA679 |
| A | TYR683 |
| A | PHE686 |
| A | PRO702 |
| A | MET703 |
| A | LYS708 |
| A | GLU711 |
| A | GLY715 |
| A | GLN716 |
| A | PHE719 |
| A | SO41007 |
| A | HOH1126 |
| A | HOH1136 |
| A | HOH1190 |
| A | HOH1233 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 801 |
| Chain | Residue |
| B | HIS519 |
| B | HIS553 |
| B | ASP554 |
| B | ASP664 |
| B | ZN802 |
| B | HOH901 |
| B | HOH956 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 802 |
| Chain | Residue |
| B | ASP554 |
| B | ZN801 |
| B | HOH901 |
| B | HOH943 |
| B | HOH955 |
| B | HOH958 |
| B | HOH959 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 803 |
| Chain | Residue |
| B | PHE472 |
| B | GLU473 |
| B | ASN474 |
| B | ARG510 |
| B | ARG558 |
| B | HIS570 |
| B | HOH909 |
| B | HOH946 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 804 |
| Chain | Residue |
| B | ARG510 |
| B | ARG511 |
| B | HOH978 |
| B | HOH992 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 805 |
| Chain | Residue |
| B | PRO673 |
| B | LYS694 |
| B | GLY697 |
| B | ILE698 |
| B | GLN699 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 806 |
| Chain | Residue |
| B | PRO673 |
| B | LYS676 |
| B | LYS694 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 807 |
| Chain | Residue |
| B | GLY597 |
| B | HIS598 |
| B | ASN599 |
| B | HOH1036 |
| B | HOH1085 |
| B | LYS497 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 808 |
| Chain | Residue |
| A | ASN645 |
| B | THR539 |
| B | ASP540 |
| B | HOH1030 |
| site_id | BC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 15J B 809 |
| Chain | Residue |
| B | TYR514 |
| B | LEU665 |
| B | THR675 |
| B | ALA679 |
| B | ILE682 |
| B | TYR683 |
| B | PHE686 |
| B | PRO702 |
| B | MET703 |
| B | LYS708 |
| B | GLU711 |
| B | GLY715 |
| B | GLN716 |
| B | PHE719 |
| B | HOH910 |
| B | HOH961 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY |
| Chain | Residue | Details |
| A | HIS553-TYR564 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 317 |
| Details | Domain: {"description":"PDEase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01192","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17389385","evidenceCode":"ECO:0000269"}]} |
