4H6D

Crystal structure of PLP-soaked HMP synthase Thi5 from S. cerevisiae

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (F, A, B, C, D...)	Pyrimidine precursor biosynthesis enzyme THI5	polymer	346	39415.6	8	UniProt (P43534) Pfam (PF09084)	Saccharomyces cerevisiae (yeast)	HMP synthase Thi5
2	I, J, K, L (A, B, E, H)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)

Sequence modifications

F, A, B, C, D, E, G, H: 1 - 340 (UniProt: P43534)

PDB	External Database	Details
Lys 101	Glu 101	engineered mutation
Ser 102	Asp 102	engineered mutation
Thr 317	Gln 317	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	315324.7
Non-Polymers*	Number of molecules	4
	Total formula weight	988.6
All*	Total formula weight	316313.3

*Water molecules are not included.