4H1S

Crystal Structure of a Truncated Soluble form of Human CD73 with Ecto-5'-Nucleotidase activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	5'-nucleotidase	polymer	530	59044.2	2	UniProt (P21589) Pfam (PF00149) Pfam (PF02872) In PDB	Homo sapiens (human)	5'-NT, Ecto-5'-nucleotidase
2	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
3	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
5		water	water		18.0	577	Chemie (HOH)

Sequence modifications

A, B: 27 - 549 (UniProt: P21589)

PDB	External Database	Details
Met 26	-	initiating methionine
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	118088.4
Non-Polymers*	Number of molecules	8
	Total formula weight	894.0
All*	Total formula weight	118982.4

*Water molecules are not included.