4H1J
Crystal structure of PYK2 with the pyrazole 13a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein-tyrosine kinase 2-beta | polymer | 293 | 33992.3 | 1 | UniProt (Q14289) Pfam (PF07714) In PDB | Homo sapiens (human) | PYK2, Calcium-dependent tyrosine kinase, CADTK, Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta, CAK-beta, CAKB, Focal adhesion kinase 2, FADK 2, Proline-rich tyrosine kinase 2, Related adhesion focal tyrosine kinase, RAFTK |
2 | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1H-pyrazol-5-yl]urea | non-polymer | 458.6 | 1 | Chemie (0YH) | |||
3 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 416 - 692 (UniProt: Q14289)
PDB | External Database | Details |
---|---|---|
Met 400 | - | expression tag |
His 401 | - | expression tag |
His 402 | - | expression tag |
His 403 | - | expression tag |
His 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
Ser 407 | - | expression tag |
Ser 408 | - | expression tag |
Gly 409 | - | expression tag |
Leu 410 | - | expression tag |
Val 411 | - | expression tag |
Pro 412 | - | expression tag |
Arg 413 | - | expression tag |
Gly 414 | - | expression tag |
Ser 415 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33992.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 458.6 | |
All* | Total formula weight | 34450.9 |