4GXX

Crystal structure of the "avianized" 1918 influenza virus hemagglutinin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (A, C, E)	Hemagglutinin HA1 chain	polymer	331	36408.8	3	UniProt (Q9WFX3) Pfam (PF00509)	Influenza A virus	Hemagglutinin receptor binding subunit
2	B, D, F (B, D, F)	Hemagglutinin HA2 chain	polymer	176	20093.1	3	UniProt (Q9WFX3) Pfam (PF00509)	Influenza A virus	Hemagglutinin membrane fusion subunit
3	G (G)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	H (H)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	I (I)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	J, K, L, M, N (A, C, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	O, P, Q, R, S... (A, B, C, D, E...)	water	water		18.0	897	Chemie (HOH)

Sequence modifications

A, C, E: 11 - 329 (UniProt: Q9WFX3)

PDB	External Database	Details
Ala 7	-	expression tag
Asp 8	-	expression tag
Pro 9	-	expression tag
Gly 10	-	expression tag
Glu 190	Asp 204	engineered mutation
Gly 225	Asp 239	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	169505.7
Branched	Number of molecules	3
	Total formula weight	2246.0
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	172857.8

*Water molecules are not included.