4GV7

Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Poly [ADP-ribose] polymerase 1	polymer	358	40199.9	4	UniProt (P09874) Pfam (PF02877) Pfam (PF00644) In PDB	Homo sapiens (human)	PARP-1
2	A, B, C, D	2-methylquinazolin-4(3H)-one	non-polymer		160.2	4	Chemie (MEW)

Sequence modifications

A, B, C, D: 662 - 1011 (UniProt: P09874)

PDB	External Database	Details
Met 661	-	expression tag
Ala 762	Val 762	SEE REMARK 999
Ala 1012	-	expression tag
His 1013	-	expression tag
His 1014	-	expression tag
His 1015	-	expression tag
His 1016	-	expression tag
His 1017	-	expression tag
His 1018	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	160799.8
Non-Polymers*	Number of molecules	4
	Total formula weight	640.7
All*	Total formula weight	161440.5

*Water molecules are not included.