4GV7
Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MEW A 1101 |
Chain | Residue |
A | HIS862 |
A | GLY863 |
A | TYR889 |
A | TYR896 |
A | PHE897 |
A | LYS903 |
A | SER904 |
A | TYR907 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MEW B 1101 |
Chain | Residue |
B | GLY863 |
B | TYR889 |
B | TYR896 |
B | PHE897 |
B | SER904 |
B | TYR907 |
B | HIS862 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MEW C 1101 |
Chain | Residue |
C | HIS862 |
C | GLY863 |
C | TYR896 |
C | LYS903 |
C | SER904 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MEW D 1101 |
Chain | Residue |
D | HIS862 |
D | GLY863 |
D | TYR896 |
D | SER904 |
D | TYR907 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 |
Chain | Residue | Details |
A | GLU988 | |
B | GLU988 | |
C | GLU988 | |
D | GLU988 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9UGN5 |
Chain | Residue | Details |
A | HIS862 | |
C | GLY871 | |
C | ARG878 | |
C | SER904 | |
D | HIS862 | |
D | GLY871 | |
D | ARG878 | |
D | SER904 | |
A | GLY871 | |
A | ARG878 | |
A | SER904 | |
B | HIS862 | |
B | GLY871 | |
B | ARG878 | |
B | SER904 | |
C | HIS862 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER782 | |
B | SER782 | |
C | SER782 | |
D | SER782 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER786 | |
B | SER786 | |
C | SER786 | |
D | SER786 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS748 | |
B | LYS748 | |
C | LYS748 | |
D | LYS748 |