4GSU

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Probable conserved lipoprotein LPPS	polymer	287	31280.7	2	UniProt (O53223) Pfam (PF17964) Pfam (PF03734)	Mycobacterium tuberculosis	LdtMt2
2	C, D (A, B)	(2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid	non-polymer		385.5	2	Chemie (DWZ)
3	E, F (A, B)	water	water		18.0	228	Chemie (HOH)

Sequence modifications

A, B: 131 - 408 (UniProt: O53223)

PDB	External Database	Details
Met 130	-	expression tag
Leu 409	-	expression tag
Glu 410	-	expression tag
His 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag
His 416	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62561.4
Non-Polymers*	Number of molecules	2
	Total formula weight	771.0
All*	Total formula weight	63332.3

*Water molecules are not included.