4GSU
Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Probable conserved lipoprotein LPPS | polymer | 287 | 31280.7 | 2 | UniProt (O53223) Pfam (PF17964) Pfam (PF03734) In PDB | Mycobacterium tuberculosis | LdtMt2 |
2 | A, B | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid | non-polymer | 385.5 | 2 | Chemie (DWZ) | |||
3 | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A, B: 131 - 408 (UniProt: O53223)
PDB | External Database | Details |
---|---|---|
Met 130 | - | expression tag |
Leu 409 | - | expression tag |
Glu 410 | - | expression tag |
His 411 | - | expression tag |
His 412 | - | expression tag |
His 413 | - | expression tag |
His 414 | - | expression tag |
His 415 | - | expression tag |
His 416 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 62561.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 771.0 | |
All* | Total formula weight | 63332.3 |