Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4GSU

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Functional Information from GO Data
ChainGOidnamespacecontents
A0016740molecular_functiontransferase activity
B0016740molecular_functiontransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE DWZ A 501
ChainResidue
AMET303
ATYR308
ATYR318
AVAL333
AHIS352
AGLY353
ACYS354
AHOH692
AHOH695

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE DWZ B 501
ChainResidue
ATHR145
BMET303
BTYR308
BTYR318
BGLY332
BHIS352
BGLY353
BCYS354

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23103390
ChainResidueDetails
AHIS336
BHIS336

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23103390
ChainResidueDetails
ACYS354
BCYS354

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP232
AGLU235
AGLY236
BASP232
BGLU235
BGLY236

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING:
ChainResidueDetails
ATYR318
ASER331
AASN356
BTYR318
BSER331
BASN356

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Binds to carbapenem drug (covalent) => ECO:0000250
ChainResidueDetails
ACYS354
BCYS354

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon