4GQB
Crystal Structure of the human PRMT5:MEP50 Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein arginine N-methyltransferase 5 | polymer | 637 | 72766.7 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) | Homo sapiens (human) | 72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, Protein arginine N-methyltransferase 5, N-terminally processed |
| 2 | B (B) | Methylosome protein 50 | polymer | 344 | 36883.3 | 1 | UniProt (Q9BQA1) Pfam (PF00400) | Homo sapiens (human) | MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50 |
| 3 | C (C) | Histone H4 peptide | polymer | 22 | 2126.5 | 1 | UniProt (P62805) | Homo sapiens | |
| 4 | D (A) | (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid | non-polymer | 379.4 | 1 | Chemie (0XU) | |||
| 5 | E, F, G (A, B, C) | water | water | 18.0 | 300 | Chemie (HOH) |
Sequence modifications
B: 2 - 342 (UniProt: Q9BQA1)
C: 1 - 21 (UniProt: P62805)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 0 | - | acetylation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 111776.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 379.4 | |
| All* | Total formula weight | 112155.9 |
