4GO2

Crystal structure of the c-terminal domain of 10'formyltetrahydrofolate dehydrogenase in complex with Thio-NADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Cytosolic 10-formyltetrahydrofolate dehydrogenase	polymer	517	56621.5	4	UniProt (P28037) Pfam (PF00171)	Rattus norvegicus (brown rat rat rats)	10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, FBP-CI
2	AA, BA, CA, DA, E... (C, A, D, B)	SULFATE ION	non-polymer		96.1	28	Chemie (SO4)
3	EA, L, MA, V (C, A, D, B)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
4	FA, M, NA, W (C, A, D, B)	7-THIONICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		759.5	4	Chemie (TAP)
5	OA, PA, QA, RA (A, B, C, D)	water	water		18.0	1023	Chemie (HOH)

Sequence modifications

A, B, C, D: 397 - 902 (UniProt: P28037)

PDB	External Database	Details
Met 386	-	expression tag
Arg 387	-	expression tag
Gly 388	-	expression tag
Ser 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
Thr 395	-	expression tag
Thr 396	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	226486.2
Non-Polymers*	Number of molecules	36
	Total formula weight	6096.0
All*	Total formula weight	232582.2

*Water molecules are not included.