4GMC

Crystal structure of HCV NS5B polymerase in complex with a thumb inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NS5B polymerase	polymer	576	64285.6	2	UniProt (O92972) Pfam (PF00998) In PDB	Hepatitis C virus (HCV)	RNA-directed RNA polymerase
2	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	B	3-cyclohexyl-2-(furan-3-yl)-1-[2-(morpholin-4-yl)-2-oxoethyl]-N-(phenylsulfonyl)-1H-indole-6-carboxamide	non-polymer		575.7	1	Chemie (1BI)
4		water	water		18.0	63	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: O92972)

PDB	External Database	Details
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128571.3
Non-Polymers*	Number of molecules	5
	Total formula weight	959.9
All*	Total formula weight	129531.2

*Water molecules are not included.