4GMC
Crystal structure of HCV NS5B polymerase in complex with a thumb inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NS5B polymerase | polymer | 576 | 64285.6 | 2 | UniProt (O92972) Pfam (PF00998) | Hepatitis C virus (HCV) | RNA-directed RNA polymerase |
| 2 | C, D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | E (B) | 3-cyclohexyl-2-(furan-3-yl)-1-[2-(morpholin-4-yl)-2-oxoethyl]-N-(phenylsulfonyl)-1H-indole-6-carboxamide | non-polymer | 575.7 | 1 | Chemie (1BI) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: O92972)
| PDB | External Database | Details |
|---|---|---|
| His 571 | - | expression tag |
| His 572 | - | expression tag |
| His 573 | - | expression tag |
| His 574 | - | expression tag |
| His 575 | - | expression tag |
| His 576 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 128571.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 959.9 | |
| All* | Total formula weight | 129531.2 |
