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4GMC

Crystal structure of HCV NS5B polymerase in complex with a thumb inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 601
ChainResidue
AARG48
ALYS51
AARG158
ATHR221
ACYS223

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 602
ChainResidue
AASN291
AGLY317
AASP318
ASER556

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE 1BI B 601
ChainResidue
BVAL37
BALA393
BALA396
BHIS428
BLEU492
BGLY493
BVAL494
BARG503

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 602
ChainResidue
BARG48
BLYS51
BARG158
BTHR221
BCYS223

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 603
ChainResidue
BPHE193
BSER288
BASN291
BGLY317
BASP318
BSER556

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P26663
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

223532

PDB entries from 2024-08-07

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