4GKI
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NM-PP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Aminoglycoside 3'-phosphotransferase AphA1-IAB | polymer | 272 | 31350.4 | 12 | UniProt (B0VD92) | Acinetobacter baumannii | |
| 2 | BC, EB, HA, KB, M... (L, H, D, I, A...) | KANAMYCIN A | non-polymer | 484.5 | 12 | Chemie (KAN) PubChem (16397788) PubChem (16757694) PubChem (815) PubChem (177675166) PubChem (16217549) PubChem (18334290) PubChem (45073406) PubChem (51432364) PubChem (53384893) PubChem (44120028) PubChem (57646393) PubChem (58058503) PubChem (58058521) PubChem (58373046) PubChem (67990918) PubChem (68011875) PubChem (68052387) PubChem (68252403) PubChem (68312130) PubChem (71018050) PubChem (71068080) PubChem (71474663) PubChem (53393564) PubChem (73265200) PubChem (73438917) PubChem (56846434) PubChem (58283957) PubChem (2735207) PubChem (68044214) PubChem (89563800) PubChem (6032) PubChem (90304917) PubChem (90346278) PubChem (90401091) PubChem (439581) PubChem (89546225) PubChem (91026991) PubChem (71112986) PubChem (92328105) PubChem (99719288) PubChem (99719287) PubChem (5311199) PubChem (101552272) PubChem (117705492) PubChem (117724293) PubChem (122691699) PubChem (124716428) PubChem (124747528) PubChem (92328106) PubChem (92328107) PubChem (92328108) PubChem (9893710) PubChem (6419439) PubChem (129051379) PubChem (131632455) PubChem (6604383) PubChem (6710653) PubChem (133612006) PubChem (11540314) PubChem (99719286) PubChem (99719289) PubChem (11569275) PubChem (134694046) PubChem (117725309) PubChem (155921367) PubChem (118912256) PubChem (122537351) PubChem (122540922) PubChem (122627361) PubChem (11274101) PubChem (11399903) PubChem (124716425) PubChem (124716426) PubChem (124716427) PubChem (124747527) PubChem (124747529) PubChem (124747530) PubChem (124762298) PubChem (124762299) PubChem (124762300) PubChem (124762301) PubChem (12305427) PubChem (12305429) PubChem (163954033) PubChem (170999936) PubChem (132989035) PubChem (134129480) PubChem (134765989) PubChem (134814279) PubChem (135016926) PubChem (137471689) PubChem (138106968) PubChem (139026184) PubChem (140574948) PubChem (154594319) PubChem (163034598) PubChem (167223866) PubChem (172182825) PubChem (173745807) PubChem (173948762) PubChem (173961295) PubChem (174029865) PubChem (175674900) | |||
| 3 | AA, CC, FB, IA, LB... (C, L, H, D, I...) | 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | non-polymer | 331.4 | 12 | Chemie (0JN) PubChem (5154691) | |||
| 4 | AB, BA, BB, CA, DC... (G, C, L, H, D...) | SODIUM ION | non-polymer | 23.0 | 14 | Chemie (NA) PubChem (923) | |||
| 5 | Q (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 6 | AC, CB, DA, DB, EA... (K, G, C, L, H...) | ACETATE ION | non-polymer | 59.0 | 28 | Chemie (ACT) PubChem (175) | |||
| 7 | NB, U, UB, VB, WB... (I, A, J, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 6 | Chemie (PEG) PubChem (8117) | |||
| 8 | HC, IC, JC, KC, LC... (A, B, C, D, E...) | water | water | 18.0 | 3308 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 271 (UniProt: B0VD92)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 376204.8 | |
| Non-Polymers* | Number of molecules | 73 |
| Total formula weight | 12438.2 | |
| All* | Total formula weight | 388643.1 |
