4GKI
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NM-PP1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0046677 | biological_process | response to antibiotic |
| C | 0005524 | molecular_function | ATP binding |
| C | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| C | 0046677 | biological_process | response to antibiotic |
| D | 0005524 | molecular_function | ATP binding |
| D | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| D | 0046677 | biological_process | response to antibiotic |
| E | 0005524 | molecular_function | ATP binding |
| E | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| E | 0046677 | biological_process | response to antibiotic |
| F | 0005524 | molecular_function | ATP binding |
| F | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| F | 0046677 | biological_process | response to antibiotic |
| G | 0005524 | molecular_function | ATP binding |
| G | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| G | 0046677 | biological_process | response to antibiotic |
| H | 0005524 | molecular_function | ATP binding |
| H | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| H | 0046677 | biological_process | response to antibiotic |
| I | 0005524 | molecular_function | ATP binding |
| I | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| I | 0046677 | biological_process | response to antibiotic |
| J | 0005524 | molecular_function | ATP binding |
| J | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| J | 0046677 | biological_process | response to antibiotic |
| K | 0005524 | molecular_function | ATP binding |
| K | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| K | 0046677 | biological_process | response to antibiotic |
| L | 0005524 | molecular_function | ATP binding |
| L | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| L | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE KAN A 301 |
| Chain | Residue |
| A | ASP165 |
| A | HOH402 |
| A | HOH408 |
| A | HOH412 |
| A | HOH416 |
| A | HOH446 |
| A | HOH447 |
| A | HOH463 |
| A | HOH470 |
| A | HOH488 |
| A | HOH581 |
| A | ASP167 |
| A | HOH587 |
| A | HOH591 |
| A | HOH605 |
| H | GLY252 |
| A | ASP198 |
| A | ASN234 |
| A | CYS235 |
| A | GLU238 |
| A | ASP268 |
| A | GLU269 |
| A | PHE271 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 0JN A 302 |
| Chain | Residue |
| A | ASP31 |
| A | PHE53 |
| A | ALA100 |
| A | ILE101 |
| A | ILE215 |
| A | HOH476 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 303 |
| Chain | Residue |
| A | THR76 |
| A | MSE79 |
| A | ACT307 |
| A | HOH569 |
| A | HOH659 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 304 |
| Chain | Residue |
| A | ASN234 |
| A | HOH402 |
| A | HOH424 |
| A | HOH445 |
| A | HOH458 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 305 |
| Chain | Residue |
| A | SER242 |
| A | LYS245 |
| L | HOH540 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 306 |
| Chain | Residue |
| A | GLY37 |
| A | ALA38 |
| A | THR39 |
| A | HIS56 |
| A | GLY57 |
| A | LYS58 |
| A | HOH594 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 307 |
| Chain | Residue |
| A | THR76 |
| A | ALA77 |
| A | MSE79 |
| A | NA303 |
| A | HOH654 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 308 |
| Chain | Residue |
| A | VAL109 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 309 |
| Chain | Residue |
| A | ARG129 |
| A | SER133 |
| A | TYR251 |
| A | HOH544 |
| A | HOH628 |
| site_id | BC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE KAN B 301 |
| Chain | Residue |
| A | SER2 |
| A | HIS3 |
| A | HOH456 |
| B | GLN35 |
| B | ASP165 |
| B | PHE166 |
| B | ASP167 |
| B | ASP198 |
| B | ARG219 |
| B | ASN234 |
| B | CYS235 |
| B | ASP268 |
| B | GLU269 |
| B | PHE271 |
| B | HOH406 |
| B | HOH413 |
| B | HOH415 |
| B | HOH433 |
| B | HOH439 |
| B | HOH444 |
| B | HOH518 |
| B | HOH550 |
| B | HOH606 |
| B | HOH671 |
| C | ARG6 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0JN B 302 |
| Chain | Residue |
| A | GLN5 |
| B | ASP31 |
| B | ILE40 |
| B | PHE53 |
| B | ALA100 |
| B | ILE101 |
| B | GLY103 |
| B | ILE215 |
| B | ASP216 |
| B | HOH425 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 303 |
| Chain | Residue |
| B | HOH437 |
| B | VAL109 |
| B | TYR113 |
| B | SER116 |
| B | GLY209 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 304 |
| Chain | Residue |
| B | ARG129 |
| B | HIS132 |
| B | SER133 |
| B | ARG225 |
| B | TYR251 |
| site_id | BC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE KAN C 301 |
| Chain | Residue |
| C | ASP165 |
| C | ASP167 |
| C | ASP198 |
| C | ASN234 |
| C | CYS235 |
| C | GLU238 |
| C | ASP268 |
| C | GLU269 |
| C | PHE271 |
| C | HOH403 |
| C | HOH408 |
| C | HOH415 |
| C | HOH443 |
| C | HOH446 |
| C | HOH460 |
| C | HOH463 |
| C | HOH508 |
| C | HOH538 |
| C | HOH596 |
| C | HOH620 |
| L | GLY252 |
| L | HOH524 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 0JN C 302 |
| Chain | Residue |
| C | PHE53 |
| C | ALA100 |
| C | ILE101 |
| C | GLY103 |
| C | ILE215 |
| C | HOH516 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 303 |
| Chain | Residue |
| C | THR76 |
| C | MSE79 |
| C | ACT308 |
| C | HOH537 |
| C | HOH563 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 304 |
| Chain | Residue |
| C | ASN234 |
| C | HOH466 |
| C | HOH469 |
| C | HOH525 |
| L | HOH524 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C 305 |
| Chain | Residue |
| C | VAL109 |
| C | TYR113 |
| C | ILE120 |
| C | HOH580 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT C 306 |
| Chain | Residue |
| C | TRP233 |
| C | GLN262 |
| C | HOH437 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 307 |
| Chain | Residue |
| C | LYS184 |
| C | LEU185 |
| C | LEU186 |
| C | PRO187 |
| C | ASN259 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 308 |
| Chain | Residue |
| C | THR76 |
| C | MSE79 |
| C | PRO80 |
| C | ARG130 |
| C | NA303 |
| site_id | CC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE KAN D 301 |
| Chain | Residue |
| C | SER2 |
| C | HIS3 |
| C | HOH600 |
| D | ASP165 |
| D | ASP167 |
| D | ASP198 |
| D | ASN234 |
| D | CYS235 |
| D | GLU238 |
| D | ASP268 |
| D | GLU269 |
| D | PHE271 |
| D | HOH418 |
| D | HOH420 |
| D | HOH430 |
| D | HOH432 |
| D | HOH439 |
| D | HOH446 |
| D | HOH492 |
| D | HOH510 |
| D | HOH550 |
| D | HOH563 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 0JN D 302 |
| Chain | Residue |
| C | GLN5 |
| D | ASP31 |
| D | ILE40 |
| D | PHE53 |
| D | ILE101 |
| D | GLY103 |
| D | ILE215 |
| D | HOH412 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 303 |
| Chain | Residue |
| D | THR76 |
| D | MSE79 |
| D | ACT304 |
| D | HOH507 |
| D | HOH526 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT D 304 |
| Chain | Residue |
| D | THR76 |
| D | ALA77 |
| D | PHE78 |
| D | MSE79 |
| D | PRO80 |
| D | NA303 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT D 305 |
| Chain | Residue |
| D | TYR113 |
| D | SER116 |
| D | HOH585 |
| D | HOH665 |
| site_id | CC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE KAN E 301 |
| Chain | Residue |
| E | GLN35 |
| E | ASP165 |
| E | PHE166 |
| E | ASP167 |
| E | ASP198 |
| E | ARG219 |
| E | ASN234 |
| E | CYS235 |
| E | GLU238 |
| E | ASP268 |
| E | GLU269 |
| E | PHE271 |
| E | HOH413 |
| E | HOH428 |
| E | HOH431 |
| E | HOH433 |
| E | HOH452 |
| E | HOH482 |
| E | HOH514 |
| E | HOH542 |
| E | HOH604 |
| E | HOH627 |
| E | HOH660 |
| site_id | DC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0JN E 302 |
| Chain | Residue |
| E | ASP31 |
| E | ILE40 |
| E | PHE53 |
| E | ALA100 |
| E | ILE101 |
| E | GLY103 |
| E | ILE205 |
| E | ILE215 |
| E | HOH408 |
| E | HOH444 |
| E | HOH558 |
| F | GLU7 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA E 303 |
| Chain | Residue |
| E | THR76 |
| E | MSE79 |
| E | ACT307 |
| E | HOH467 |
| E | HOH520 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT E 304 |
| Chain | Residue |
| E | ASP168 |
| E | GLU169 |
| E | ASN171 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT E 305 |
| Chain | Residue |
| E | GLU169 |
| E | TRP233 |
| E | MSE258 |
| E | LEU261 |
| E | GLN262 |
| E | LEU265 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT E 306 |
| Chain | Residue |
| D | PHE239 |
| E | ARG30 |
| E | THR39 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT E 307 |
| Chain | Residue |
| E | THR76 |
| E | ALA77 |
| E | PHE78 |
| E | MSE79 |
| E | PRO80 |
| E | NA303 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E 308 |
| Chain | Residue |
| E | VAL109 |
| E | SER116 |
| E | GLY209 |
| E | HOH459 |
| site_id | DC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN F 301 |
| Chain | Residue |
| F | ASP165 |
| F | PHE166 |
| F | ASP167 |
| F | ASP198 |
| F | ARG219 |
| F | ASN234 |
| F | CYS235 |
| F | GLU238 |
| F | ASP268 |
| F | GLU269 |
| F | PHE271 |
| F | HOH411 |
| F | HOH415 |
| F | HOH421 |
| F | HOH423 |
| F | HOH431 |
| F | HOH434 |
| F | HOH471 |
| F | HOH473 |
| F | HOH532 |
| F | HOH612 |
| site_id | DC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 0JN F 302 |
| Chain | Residue |
| E | ARG6 |
| F | ASP31 |
| F | PHE53 |
| F | ALA100 |
| F | ILE101 |
| F | GLY103 |
| F | ILE215 |
| F | HOH460 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA F 303 |
| Chain | Residue |
| F | THR76 |
| F | MSE79 |
| F | HOH600 |
| F | HOH641 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT F 304 |
| Chain | Residue |
| F | GLY37 |
| F | THR39 |
| F | HIS56 |
| F | GLY57 |
| F | LYS58 |
| F | VAL61 |
| site_id | EC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE KAN G 301 |
| Chain | Residue |
| E | GLY252 |
| E | ASP254 |
| E | HOH533 |
| G | ASP165 |
| G | ASP167 |
| G | ASP198 |
| G | ASN234 |
| G | CYS235 |
| G | GLU238 |
| G | ASP268 |
| G | GLU269 |
| G | PHE271 |
| G | HOH402 |
| G | HOH406 |
| G | HOH413 |
| G | HOH423 |
| G | HOH434 |
| G | HOH465 |
| G | HOH481 |
| G | HOH490 |
| G | HOH492 |
| G | HOH523 |
| G | HOH587 |
| G | HOH599 |
| site_id | EC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 0JN G 302 |
| Chain | Residue |
| G | ASP31 |
| G | ARG42 |
| G | PHE53 |
| G | ILE101 |
| G | HOH581 |
| G | HOH621 |
| G | HOH622 |
| G | HOH642 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA G 303 |
| Chain | Residue |
| G | THR76 |
| G | MSE79 |
| G | HOH529 |
| G | HOH541 |
| G | HOH708 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA G 304 |
| Chain | Residue |
| E | ASP254 |
| E | HOH533 |
| G | ASN234 |
| G | HOH426 |
| G | HOH516 |
| G | HOH530 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT G 305 |
| Chain | Residue |
| G | TRP233 |
| G | GLN262 |
| G | LEU265 |
| G | HOH598 |
| site_id | EC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT G 306 |
| Chain | Residue |
| G | TYR113 |
| G | HOH509 |
| site_id | EC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE KAN H 301 |
| Chain | Residue |
| G | SER2 |
| G | HIS3 |
| H | ASP165 |
| H | PHE166 |
| H | ASP167 |
| H | ASP198 |
| H | ASN234 |
| H | CYS235 |
| H | GLU238 |
| H | ASP268 |
| H | GLU269 |
| H | PHE271 |
| H | HOH411 |
| H | HOH438 |
| H | HOH449 |
| H | HOH458 |
| H | HOH459 |
| H | HOH473 |
| H | HOH477 |
| H | HOH508 |
| H | HOH517 |
| H | HOH560 |
| H | HOH598 |
| site_id | FC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0JN H 302 |
| Chain | Residue |
| G | GLN5 |
| H | ASP31 |
| H | ILE40 |
| H | PHE53 |
| H | ALA100 |
| H | ILE101 |
| H | GLY103 |
| H | ILE215 |
| H | ASP216 |
| H | HOH410 |
| site_id | FC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA H 303 |
| Chain | Residue |
| H | THR76 |
| H | MSE79 |
| H | ACT304 |
| H | HOH521 |
| H | HOH628 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT H 304 |
| Chain | Residue |
| H | THR76 |
| H | ALA77 |
| H | MSE79 |
| H | PRO80 |
| H | NA303 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT H 305 |
| Chain | Residue |
| H | TRP233 |
| H | MSE258 |
| H | GLN262 |
| H | HOH660 |
| site_id | FC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT H 306 |
| Chain | Residue |
| H | VAL109 |
| H | SER116 |
| H | HOH485 |
| site_id | FC6 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE KAN I 301 |
| Chain | Residue |
| G | ARG6 |
| G | HOH466 |
| G | HOH571 |
| I | GLN35 |
| I | ASP165 |
| I | ASP167 |
| I | ASP198 |
| I | ARG219 |
| I | ASN234 |
| I | CYS235 |
| I | ASP268 |
| I | GLU269 |
| I | PHE271 |
| I | HOH418 |
| I | HOH428 |
| I | HOH431 |
| I | HOH432 |
| I | HOH459 |
| I | HOH476 |
| I | HOH484 |
| I | HOH500 |
| I | HOH534 |
| I | HOH570 |
| I | HOH622 |
| J | SER2 |
| J | HIS3 |
| site_id | FC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 0JN I 302 |
| Chain | Residue |
| I | ASP31 |
| I | ILE40 |
| I | PHE53 |
| I | THR99 |
| I | ALA100 |
| I | ILE101 |
| I | GLY103 |
| I | ILE215 |
| J | GLN5 |
| site_id | FC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT I 303 |
| Chain | Residue |
| I | VAL109 |
| I | GLY209 |
| K | PRO241 |
| site_id | FC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG I 304 |
| Chain | Residue |
| I | ARG129 |
| I | SER133 |
| I | ARG225 |
| I | TYR251 |
| I | HOH482 |
| site_id | GC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE KAN J 301 |
| Chain | Residue |
| D | GLY252 |
| D | ASP254 |
| J | ASP165 |
| J | ASP167 |
| J | ASP198 |
| J | ASN234 |
| J | CYS235 |
| J | GLU238 |
| J | ASP268 |
| J | GLU269 |
| J | PHE271 |
| J | HOH405 |
| J | HOH410 |
| J | HOH432 |
| J | HOH445 |
| J | HOH469 |
| J | HOH475 |
| J | HOH510 |
| J | HOH594 |
| J | HOH603 |
| J | HOH608 |
| site_id | GC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0JN J 302 |
| Chain | Residue |
| J | ASP31 |
| J | ILE40 |
| J | PHE53 |
| J | LYS55 |
| J | ALA100 |
| J | ILE101 |
| J | GLY103 |
| J | THR105 |
| J | ILE205 |
| J | ILE215 |
| J | HOH451 |
| J | HOH684 |
| site_id | GC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA J 303 |
| Chain | Residue |
| J | THR76 |
| J | MSE79 |
| J | ACT306 |
| J | HOH459 |
| J | HOH683 |
| site_id | GC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA J 304 |
| Chain | Residue |
| J | ASN234 |
| J | HOH410 |
| J | HOH425 |
| J | HOH428 |
| J | HOH461 |
| site_id | GC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT J 305 |
| Chain | Residue |
| J | VAL109 |
| J | TYR113 |
| J | SER116 |
| site_id | GC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT J 306 |
| Chain | Residue |
| J | MSE79 |
| J | PRO80 |
| J | NA303 |
| site_id | GC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG J 307 |
| Chain | Residue |
| J | GLY37 |
| J | THR39 |
| J | HIS56 |
| J | LYS58 |
| J | VAL61 |
| site_id | GC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG J 308 |
| Chain | Residue |
| J | ARG129 |
| J | SER133 |
| J | GLY252 |
| site_id | GC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG J 309 |
| Chain | Residue |
| C | GLN153 |
| J | ASN158 |
| J | HOH601 |
| J | HOH663 |
| site_id | HC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE KAN K 301 |
| Chain | Residue |
| K | GLN35 |
| K | ASP165 |
| K | ASP167 |
| K | ASP198 |
| K | ARG219 |
| K | ASN234 |
| K | CYS235 |
| K | GLU238 |
| K | ASP268 |
| K | GLU269 |
| K | PHE271 |
| K | HOH402 |
| K | HOH412 |
| K | HOH424 |
| K | HOH432 |
| K | HOH447 |
| K | HOH509 |
| K | HOH519 |
| K | HOH524 |
| K | HOH539 |
| site_id | HC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 0JN K 302 |
| Chain | Residue |
| K | ASP31 |
| K | PHE53 |
| K | THR99 |
| K | ALA100 |
| K | ILE101 |
| K | GLY103 |
| K | ILE215 |
| K | ASP216 |
| K | HOH586 |
| site_id | HC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA K 303 |
| Chain | Residue |
| K | THR76 |
| K | MSE79 |
| K | HOH502 |
| K | HOH597 |
| site_id | HC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT K 304 |
| Chain | Residue |
| K | GLY37 |
| K | ALA38 |
| K | THR39 |
| K | HIS56 |
| K | LYS58 |
| K | VAL61 |
| site_id | HC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE KAN L 301 |
| Chain | Residue |
| A | ARG6 |
| K | SER2 |
| K | HOH421 |
| L | GLN35 |
| L | ASP165 |
| L | PHE166 |
| L | ASP167 |
| L | ASP198 |
| L | ARG219 |
| L | ASN234 |
| L | CYS235 |
| L | GLU238 |
| L | ASP268 |
| L | GLU269 |
| L | PHE271 |
| L | HOH409 |
| L | HOH421 |
| L | HOH426 |
| L | HOH436 |
| L | HOH448 |
| L | HOH458 |
| L | HOH484 |
| L | HOH490 |
| L | HOH491 |
| L | HOH543 |
| L | HOH551 |
| L | HOH623 |
| site_id | HC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 0JN L 302 |
| Chain | Residue |
| L | ASP31 |
| L | ILE40 |
| L | PHE53 |
| L | ALA100 |
| L | ILE101 |
| L | GLY103 |
| L | ILE215 |
| L | ASP216 |
| L | HOH432 |
| site_id | HC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA L 303 |
| Chain | Residue |
| L | THR76 |
| L | MSE79 |
| L | ACT304 |
| L | HOH482 |
| L | HOH509 |
| site_id | HC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT L 304 |
| Chain | Residue |
| L | THR76 |
| L | ALA77 |
| L | PHE78 |
| L | MSE79 |
| L | PRO80 |
| L | NA303 |
| site_id | HC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT L 305 |
| Chain | Residue |
| L | TRP233 |
| site_id | IC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT L 306 |
| Chain | Residue |
| L | LEU81 |
| L | HOH657 |
Functional Information from PROSITE/UniProt
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VTHgDFSLDNLIF |
| Chain | Residue | Details |
| A | VAL194-PHE206 |
