4G5J
Crystal structure of EGFR kinase in complex with BIBW2992
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 330 | 37579.5 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | non-polymer | 488.0 | 1 | Chemie (0WN) | |||
| 3 | C, D (A) | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide | non-polymer | 485.9 | 2 | Chemie (0WM) | |||
| 4 | E (A) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37579.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1459.8 | |
| All* | Total formula weight | 39039.3 |
