4G1N

PKM2 in complex with an activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Pyruvate kinase isozymes M1/M2	polymer	518	56657.3	4	UniProt (P14618) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (human)	Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58
2	E, H, J, L (A, B, C, D)	OXALATE ION	non-polymer		88.0	4	Chemie (OXL)
3	F, I, K, M (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	G, N (A, D)	N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]carbonyl}phenyl)quinoline-8-sulfonamide	non-polymer		474.5	2	Chemie (NZT)
5	O, P, Q, R (A, B, C, D)	water	water		18.0	222	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	226629.2
Non-Polymers*	Number of molecules	10
	Total formula weight	1398.4
All*	Total formula weight	228027.5

*Water molecules are not included.