4FX6
Crystal structure of the mutant V182A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (M, N) | Orotidine 5'-phosphate decarboxylase | polymer | 228 | 24770.5 | 2 | UniProt (O26232) Pfam (PF00215) | Methanothermobacter thermautotrophicus str. Delta H | OMP decarboxylase, OMPDCase, OMPdecase |
| 2 | C, G (M, N) | 6-HYDROXYURIDINE-5'-PHOSPHATE | non-polymer | 340.2 | 2 | Chemie (BMP) | |||
| 3 | D, E, F, H (M, N) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | I, J (M, N) | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence modifications
M, N: 1 - 228 (UniProt: O26232)
| PDB | External Database | Details |
|---|---|---|
| Pro 101 | Arg 101 | conflict |
| Ala 182 | Val 182 | engineered mutation |
| Ala 203 | Arg 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49541.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1048.7 | |
| All* | Total formula weight | 50589.8 |
