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4FX6

Crystal structure of the mutant V182A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Functional Information from GO Data
ChainGOidnamespacecontents
M0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
M0005829cellular_componentcytosol
M0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
M0006221biological_processpyrimidine nucleotide biosynthetic process
M0016831molecular_functioncarboxy-lyase activity
M0044205biological_process'de novo' UMP biosynthetic process
N0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
N0005829cellular_componentcytosol
N0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
N0006221biological_processpyrimidine nucleotide biosynthetic process
N0016831molecular_functioncarboxy-lyase activity
N0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE BMP M 301
ChainResidue
MASP20
MALA203
MHOH409
MHOH410
MHOH411
MHOH412
MHOH414
MHOH427
MHOH432
MHOH455
MHOH467
MLYS42
NASP75
NILE76
NTHR79
MASP70
MLYS72
MMET126
MSER127
MPRO180
MGLN185
MGLY202

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL M 302
ChainResidue
MTHR159
MPRO161
MGLY186
MHOH516
NASN210
NHOH420
NHOH422
NHOH469

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL M 303
ChainResidue
MPRO77
MGLU78
NHIS128
NGLN185
NHOH423
NHOH433

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL M 304
ChainResidue
MGLY52
MMET53
MASP54
MHOH521
NSER50
NGLY52
NHOH464

site_idAC5
Number of Residues21
DetailsBINDING SITE FOR RESIDUE BMP N 301
ChainResidue
MASP75
MILE76
MTHR79
NASP20
NLYS42
NASP70
NLYS72
NMET126
NSER127
NPRO180
NGLN185
NGLY202
NALA203
NGOL302
NHOH402
NHOH403
NHOH404
NHOH411
NHOH417
NHOH436
NHOH439

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL N 302
ChainResidue
NALA184
NGLN185
NALA203
NTYR206
NBMP301
NHOH417
NHOH433
NHOH461
NHOH548
NHOH593

Functional Information from PROSITE/UniProt
site_idPS00156
Number of Residues14
DetailsOMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN
ChainResidueDetails
MILE67-ASN80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor
ChainResidueDetails
MLYS72
NLYS72

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING:
ChainResidueDetails
MASP20
NASP70
NSER127
NPRO180
NGLY202
NALA203
MLYS42
MASP70
MSER127
MPRO180
MGLY202
MALA203
NASP20
NLYS42

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PDB entries from 2024-11-13

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