4FSE
crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with N-(N-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, D, E | Beta-secretase 1 | polymer | 455 | 50220.5 | 4 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 |
2 | A, B, D, E | N-[N-(4-amino-3,5-dichlorobenzyl)carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide | non-polymer | 464.4 | 4 | Chemie (0VA) | |||
3 | A, B, D, E | IODIDE ION | non-polymer | 126.9 | 9 | Chemie (IOD) | |||
4 | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, B, D, E: 1 - 441 (UniProt: P56817)
PDB | External Database | Details |
---|---|---|
Met -13 | - | EXPRESSION TAG |
Ala -12 | - | EXPRESSION TAG |
Ser -11 | - | EXPRESSION TAG |
Met -10 | - | EXPRESSION TAG |
Thr -9 | - | EXPRESSION TAG |
Gly -8 | - | EXPRESSION TAG |
Gly -7 | - | EXPRESSION TAG |
Gln -6 | - | EXPRESSION TAG |
Gln -5 | - | EXPRESSION TAG |
Met -4 | - | EXPRESSION TAG |
Gly -3 | - | EXPRESSION TAG |
Arg -2 | - | EXPRESSION TAG |
Gly -1 | - | EXPRESSION TAG |
Ser 0 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 200882.0 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2999.6 | |
All* | Total formula weight | 203881.6 |