4FSE

crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with N-(N-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0016020	cellular_component	membrane
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0VA A 501

Chain	Residue
A	LEU78
A	ILE274
A	ASP276
A	GLY278
A	THR279
A	ARG283
A	THR377
A	HOH635
A	ASP80
A	TYR119
A	GLN121
A	GLY122
A	LYS155
A	PHE156
A	TRP163
A	TYR246

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 502

Chain	Residue
A	ASN281

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site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 0VA B 501

Chain	Residue
B	LEU78
B	ASP80
B	TYR119
B	THR120
B	GLN121
B	GLY122
B	LYS155
B	PHE156
B	TRP163
B	TYR246
B	ILE274
B	ASP276
B	GLY278
B	THR279
B	ARG283
B	THR377
B	VAL380
B	HOH730

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 502

Chain	Residue
B	ASN281

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0VA D 501

Chain	Residue
D	ASP80
D	TYR119
D	THR120
D	GLN121
D	GLY122
D	LYS155
D	PHE156
D	TRP163
D	TYR246
D	ILE274
D	ASP276
D	GLY278
D	THR279
D	ARG283
D	THR377
D	HOH653

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 502

Chain	Residue
D	ASN281

---

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0VA E 501

Chain	Residue
E	LEU78
E	ASP80
E	GLY82
E	TYR119
E	THR120
E	GLN121
E	GLY122
E	LYS155
E	PHE156
E	TRP163
E	TYR246
E	ILE274
E	ASP276
E	GLY278
E	THR279
E	ARG283
E	THR377
E	HOH623
E	HOH667

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV

Chain	Residue	Details
A	ILE77-VAL88

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1364
Details	Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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