4FQX
Crystal structure of HLA-DM bound to HLA-DR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | HLA class II histocompatibility antigen, DM alpha chain | polymer | 203 | 22992.9 | 1 | UniProt (P28067) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DMA, Really interesting new gene 6 protein |
| 2 | B (D) | HLA class II histocompatibility antigen, DM beta chain | polymer | 199 | 22233.2 | 1 | UniProt (P28068) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DMB, Really interesting new gene 7 protein |
| 3 | C (E) | Synthetic peptide | polymer | 11 | 1206.5 | 1 | |||
| 4 | D (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 191 | 22111.9 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 5 | E (B) | HLA class II histocompatibility antigen, DRB1-1 beta chain | polymer | 208 | 23735.4 | 1 | UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911) | Homo sapiens (human) | MHC class II antigen DRB1*1, DR-1, DR1 |
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G, H, I, J, K (C, D, E, A, B) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
C: 1 - 199 (UniProt: P28067)
D: 1 - 193 (UniProt: P28068)
A: 1 - 191 (UniProt: P01903)
B: 1 - 192 (UniProt: P04229)
| PDB | External Database | Details |
|---|---|---|
| Gln 136 | His 162 | variant |
| His 137 | Asp 163 | variant |
| Asp 165 | Asn 191 | engineered mutation |
| Leu 200 | - | expression tag |
| Val 201 | - | expression tag |
| Pro 202 | - | expression tag |
| Arg 203 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 46 | Cys 64 | engineered mutation |
| Asp 92 | Asn 110 | engineered mutation |
| Gly 194 | - | expression tag |
| Cys 195 | - | expression tag |
| Leu 196 | - | expression tag |
| Val 197 | - | expression tag |
| Pro 198 | - | expression tag |
| Arg 199 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Cys 65 | Val 90 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Val -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Ser 30 | Cys 59 | engineered mutation |
| Ser 193 | - | expression tag |
| Gly 194 | - | expression tag |
| Gly 195 | - | expression tag |
| Gly 196 | - | expression tag |
| Ser 197 | - | expression tag |
| Leu 198 | - | expression tag |
| Pro 199 | - | expression tag |
| Ala 200 | - | expression tag |
| Thr 201 | - | expression tag |
| Gly 202 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 92279.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| All* | Total formula weight | 92704.3 |
