4FP8

Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hemagglutinin HA1 chain	polymer	278	30731.4	4	UniProt (Q91MA7) Pfam (PF00509)	Influenza A virus	Hemagglutinin receptor binding subunit HA1
2	E, G, I, K (H, I, J, K)	Antibody C05, heavy chain	polymer	241	25474.4	4		Homo sapiens (human)
3	F, H, J, L (L, M, N, O)	Antibody C05, light chain	polymer	214	23367.0	4		Homo sapiens (human)
4	M (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	N, O (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	P, Q, R, S, T... (H, L, M, J, N...)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)

Sequence modifications

A, B, C, D: 43 - 309 (UniProt: Q91MA7)

PDB	External Database	Details
Ala 39	-	expression tag
Asp 40	-	expression tag
Pro 41	-	expression tag
Gly 42	-	expression tag
Gly 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	318291.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	10
	Total formula weight	965.7
All*	Total formula weight	319681.4

*Water molecules are not included.