4FMN

Structure of the C-terminal domain of the Saccharomyces cerevisiae MUTL alpha (MLH1/PMS1) heterodimer bound to a fragment of NTG2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA mismatch repair protein MLH1	polymer	288	33239.1	1	UniProt (P38920) Pfam (PF16413)	Saccharomyces cerevisiae (yeast)	MutL protein homolog 1, Post meiotic segregation protein 2
2	B (B)	DNA mismatch repair protein PMS1	polymer	240	27948.2	1	UniProt (P14242) Pfam (PF08676)	Saccharomyces cerevisiae (yeast)	Postmeiotic segregation protein 1
3	C (C)	DNA repair peptide	polymer	9	1085.3	1	UniProt (Q08214)	Saccharomyces cerevisiae	Ntg2 (DNA N-glycosylase and apurinic or apyrimidinic lyase)
4	D, E, F, G, H (A)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	I, J, K, L, M... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
6	N, O (B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	Q, R (A, B)	water	water		18.0	131	Chemie (HOH)

Sequence modifications

A: 485 - 769 (UniProt: P38920)

PDB	External Database	Details
Gly 482	-	expression tag
Ala 483	-	expression tag
Met 484	-	expression tag

B: 635 - 873 (UniProt: P14242)

PDB	External Database	Details
Gly 634	-	expression tag

C: 22 - 29 (UniProt: Q08214)

PDB	External Database	Details
Ace 21	-	acetylation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	62272.6
Non-Polymers*	Number of molecules	13
	Total formula weight	963.7
All*	Total formula weight	63236.3

*Water molecules are not included.