4FL5
Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein sigma | polymer | 236 | 26558.9 | 2 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1, Stratifin |
| 2 | C, D (P, Q) | Microtubule-associated protein tau | polymer | 10 | 1133.2 | 2 | UniProt (P10636) | Homo sapiens | Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau |
| 3 | E, F (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | G, H, P, Q (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | I, J, K, L, M... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 6 | N, O, S (A, P) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | T, U, V, W (A, B, P, Q) | water | water | 18.0 | 529 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55384.2 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 684.9 | |
| All* | Total formula weight | 56069.0 |
