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4FL5

Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS214

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0022407biological_processregulation of cell-cell adhesion
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0032880biological_processregulation of protein localization
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A0141156biological_processcAMP/PKA signal transduction
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1903829biological_processpositive regulation of protein localization
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001836biological_processrelease of cytochrome c from mitochondria
B0003334biological_processkeratinocyte development
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0010839biological_processnegative regulation of keratinocyte proliferation
B0019901molecular_functionprotein kinase binding
B0022407biological_processregulation of cell-cell adhesion
B0030216biological_processkeratinocyte differentiation
B0030307biological_processpositive regulation of cell growth
B0031424biological_processkeratinization
B0032880biological_processregulation of protein localization
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043616biological_processkeratinocyte proliferation
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0051726biological_processregulation of cell cycle
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0072089biological_processstem cell proliferation
B0140311molecular_functionprotein sequestering activity
B0141156biological_processcAMP/PKA signal transduction
B1903077biological_processnegative regulation of protein localization to plasma membrane
B1903829biological_processpositive regulation of protein localization
B2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 301
ChainResidue
ATHR136
AGLY137
AASP138
AASP139
AHOH663

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 303
ChainResidue
AHOH629
AHOH637
ATHR228
ATHR231
AHOH626
AHOH627

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 304
ChainResidue
AGLU86
AGLU89
AHOH633
AHOH634

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 305
ChainResidue
AHOH476
AHOH498
AHOH547
AHOH624
AHOH630
AHOH664

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 306
ChainResidue
AGLU2
AHOH426
AHOH432
BGLU2
BHOH417
BHOH549

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 307
ChainResidue
AGLU161
AHOH414
AHOH568
AHOH579
AHOH588
AHOH613

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 308
ChainResidue
AGLU35
AGLU110
AGLU188
AHOH500
AHOH591

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA A 309
ChainResidue
AHOH553
AHOH589
BLYS9

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 310
ChainResidue
APHE198
AMET202
ATHR217
AGLN221
AHOH621
AHOH635
AHOH636
AHOH651
BGLU110
BHOH531

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 311
ChainResidue
AGLU17
AHOH639
BLYS159
BLYS160
BMET162
BHOH469
BHOH611

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 301
ChainResidue
AHOH640
AHOH644
BHOH469
BHOH518
BHOH611

site_idBC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 302
ChainResidue
AGLU80
AHOH557
BGLU2
BALA4
BSER5
BHOH449
BHOH481

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA B 303
ChainResidue
ALYS9
BHOH454
BHOH632

site_idBC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL P 301
ChainResidue
AHOH544
BASP199
BHOH593
PPRO213
PSEP214
PLEU215
PPRO216
PHOH406
PHOH408
PHOH414

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:9614189
ChainResidueDetails
PTHR212
QTHR212
BARG56
BARG129

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:9614189
ChainResidueDetails
PSEP214
QSEP214

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179
ChainResidueDetails
PTHR217
QTHR217

224004

PDB entries from 2024-08-21

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