4FGT
Allosteric peptidic inhibitor of human thymidylate synthase that stabilizes inactive conformation of the enzyme.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thymidylate synthase | polymer | 325 | 37262.6 | 1 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (human) | TS, TSase |
| 2 | B (D) | CG peptide | polymer | 4 | 525.6 | 1 | Synthetic | ||
| 3 | C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 29 - 311 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Ala 47 | Lys 47 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37788.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 38076.4 |
